Neuro Plus Brain and Focus

Vitamin B1 (Thiamine)

• Supports aerobic energy metabolism (oxidative phosphorylation), cell growth, optimal neuronal conduction (nerve impulses), and cardiovascular health (94).

• Supports cardiovascular function and aids as a neuroprotective agent in individuals with vitamin B-1 deficiencies (94, 95).

Vitamin B2 (Riboflavin)

• Supports conversion and activation of other B vitamins, red blood cell production and serves as a cofactor for both glucose and fat metabolism (energy production) (92,93).

Vitamin B3 (Niacin)

• Major B vitamin that supports cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reducing very low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (9).
• Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (9).
• Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (9).
• Supports healthy inflammatory response via antioxidant and anti-apoptotic (prevention of cell death) properties (9).
• Prevents pathologies(diseases) such as Pellagra and reduces prevalence of nervous anorexia, cancer, and crohn's disease (10, 11).
• Supports sensitization of tumors to radiation via apoptosis (cell death) cascade of tumor mass and improves oxygen delivery to malignant tissues (cancer cells) (12).
• Supports cognitive health by reducing age-related decline of NAD+, increasing quinolinic acid and reducing neuroinflammation (9).
• Increased niacin associated NAD+ levels have been shown to increase neurotransmission, learning and memory (9).
• Niacin reduces the prevalence of neurodegenerative pathologies by preventing mitochondrial dysfunction (9).

Vitamin B6

• Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40).
• Reduces plasma glucose (blood sugar levels) via by inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39).
• Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40).
• May support blood sugar regulation in women with gestational diabetes (40).
• Cofactor for enzymes involved in DNA metabolism (40).

Folic Acid

• May support proper cell growth and DNA synthesis (65).

Biotin

• Supports conversion of food into cellular energy, hair health, skin health, and cognitive function (213,214).

• Enhances glucose breakdown into skeletal muscle tissue (213,214).

Vitamin B5

• Supports energy production, cell growth, cell repair, cognitive function, increased hippocampal volume (memory), and optimized bioenergetics (burning of carbohydrates, fat, and protein) (96).

Calcium

• Supports bone health, muscle function, and cardiovascular health (36,37).
• Regulates processes of bone resorption, mineralization, and fracture repair (36,37).

• Increases the effect of physical exercise on bone mineral acquisition in the period preceding puberty (36,37).
• Prevents the development of preeclampsia (36,37).

Iron

• Supports red blood cell formation, immune function, and antioxidant support (215,216).
• May increases oxygen uptake into red blood cells of Iron deficient individuals (215,216).

• May support gut health of iron-deficient individuals.
• Combats anemia in Iron deficient individuals (217).

Magnesium

• Supports optimal nerve function, muscle contractions, cardiovascular, bone health, and decreased anxiety (90,91).

• Supports biological reactions such as ATP-fueled reactions and pancreatic insulin secretion (90,91).

• Supports reduction systolic blood pressure, fasting glucose, triglycerides, and healthy HDL levels (90,91).

• Reduces peripheral cortisol levels in the CNS and supports relaxation and decreased anxiety (90,91).

Zinc

• Supports immune function, skin health, cognitive function, and vision (172,173).
• Supports stimulation of the innate and adaptive immune system (172,173).
• Supports the activation of lymphocytes and activation of innate and T cell-mediated immunity (172,173).
• Supports cognitive function by modulation of neuronal signaling in areas of the brain associated with memory and learning (hippocampus) (172,173).

Selenium

• Supports antioxidant function, cardiovascular health, cognitive function, thyroid health, and immune health (145, 146).

• Combats atherosclerosis, high cholesterol (hypercholesterolemia), and type 1 diabetes (147).

• Supports thyroid health via decreased circulating thyroid autoantibodies in patients with chronic autoimmune thyroiditis (AIT) (146).

• Increases the activity of selenoproteins that decrease reactive oxygen species (inflammation), increase natural killer activity, and increases glutathione (master antioxidant) levels (145,147).

Copper

• Supports healthy blood sugar levels, energy metabolism and cholesterol management (143,144).

Manganese

• Supports enzymatic antioxidant reactions, increased bone mineral density, and blood sugar regulation (148,149).

Chromium

• Supports insulin function, reduced cholesterol, improved blood sugar regulation, and may lower cholesterol (218,219).

Molybdenum

• Increases enzymatic reactions involved in sulfite metabolism and detoxification (150).

DMAE Bitartrate

• Increases acetylcholine levels in the brain.

L-Glutamine

• The most abundant amino acid in skeletal muscle that fuels immune cells, improves exercise recovery, and optimizes gut microbiome (18).
• Vital for lymphocyte (immune cell) proliferation (growth) and paramount in neutrophil (immune cell) destruction of bacteria (18).
• Vital for activation of genetic signals that support immune function and vitality (18).
• Glutamine is utilized by immune cells at high rates during catabolic conditions (post-surgery, sepsis, burns, and extreme exercise (18).

Glutamic Acid

• Supports cognitive function and focus (220).

Green Tea Extract

• A potent polyphenolic antioxidant that supports blood pressure, insulin sensitivity, and metabolic health (26).
• High in ECGC (epigallocatechin gallate) (26).
• ECGC is shown to reduce body fat mass, increase fat oxidation(burning) and increase caloric expenditure during exercise (25).
• Potent anti-inflammatory compound supporting glutathione production and inhibition of pro-inflammatory markers (cytokines) (26).
• Reduces oxidative stress (chronic inflammation in the body) (26).

Choline

• Essential for cell membrane integrity, cell messaging, fat metabolism, DNA synthesis, immune support, and nervous system function (62,63).
• Serves as a methyl donor and as a precursor for the production of cell membranes (62).
• Precursor for acetylcholine (neurotransmitter) which activates receptors in the central nervous system-mediated immune responses (α7nAchR) (64).
• Lifelong choline supplementation may combat neurodegenerative diseases by reducing amyloid-β plaque load (plaques of degrading neurons) (62).
• Reduces the concentration of total homocysteine (inflammation marker) in individuals with low levels of folate and other B vitamins (B₂, B₆, and B₁₂) (62).

Inositol

• Supports liver detoxification, combats metabolic syndrome, and aids as an antioxidant (221).
• Combats metabolic syndrome via reduced levels of triglycerides, total- and LDL-cholesterol (221).
• Supports antioxidant function via reduced levels of reactive oxygen species and inflammatory markers (interleukin 6) (222).

N-Acetyl Tyrosine

• Supports memory, cognitive flexibility, the executive function of the brain, and convergent thinking (60).
• The precursor to dopamine and is vital for dopamine synthesis in the brain (60).

• Supports cognitive function in individuals with high amounts of stress and anxiety (60,61).
• Increases dopamine levels in highly stressed individuals (60).

Bilberry Fruit

• Supports vision health, cardiovascular function, increased nitric oxide production, and antioxidant support (223,224).

Grape Seed Extract

• Supports increased nitric oxide production, reduces blood pressure, reduces DNA damage, increases collagen production, increases bone strength, and aids as a neuroprotective agent (31).
• Supports antioxidant function via modulation of antioxidant enzyme expression, protection against oxidative damage, and reduced reactive oxygen species (31).

• Supports cardiovascular health via reduced atherosclerosis, inhibiting lipid peroxidation, and improved endothelial vascular function (31).

Olive Leaf

• Supports cardiovascular health, antioxidant function, and controlled blood sugar levels (224).
• Supports Cardiovascular health via reduction of systolic BP, LDL, and inflammatory biomarkers (224).
• Supports antioxidant function via anti-inflammatory polyphenols that protect against DNA damage initiated by free radicals (225).
• Combats major inflammatory pathways via anti-inflammatory change involving inflammation pathway (NF-κB inhibition) (225).
• Supports blood sugar regulation via improved insulin sensitivity and pancreatic β-cell (cells responsible for secreting insulin) secretory capacity (226).

Licorice Root

• Supports anti-inflammatory, anti-allergenic, and antimicrobial properties (177).

Boron

• Supports increased bone mineral density, muscle function, hormonal balance, and immune function (180).

DHA (Fish Oil)

• Vital for optimal cardiovascular, hormonal, immune, cognitive, digestive health, and recovery from exercise (73,74,76).
• Fish oil consumption of 6 grams per day has been shown to reduce inflammation, reduce muscle soreness, and reduced the perception of pain in exercising individuals (76).
• Increases skeletal muscle hypertrophy than individuals consuming only whey protein post-exercise (76).
• Supports cardiovascular health by decreasing atrial fibrillation, atherosclerosis (plaque buildup), thrombosis, blood pressure, and supporting blood lipid profiles (cholesterol panel) (73,74,75).
• Lowers blood pressure via increased production nitric oxide production and induced endothelial relaxation (75).
• Supports healthy information by decreasing c-reactive protein (inflammatory markers) in the body and increasing insulin sensitivity (75,76).
• Supports cognitive health by increasing the concentration of omega 3 fatty acids in the cell membranes of the cerebral cortex and synaptic vesicles (76).

Vanadyl Sulfate

• Supports blood sugar regulation via improved insulin sensitivity and pancreatic beta-cell function (cells that produce insulin) (227).

Phosphatidylserine

• Supports cognitive function, memory, and focus, and reduced stress (228,229).
• Reduces prevalence of short-term memory loss in ADHD patients improved prefrontal cortex (PFC) pyramidal cells function (228).
• Increases dopamine and acetylcholine release via maintenance of acetylcholine supply (228).
• Reduces cortisol levels in the frontal Brian regions during stressful activity (228,229).

Huperzine A

• Supports cognitive function, memory, focus, and combats neurodegenerative disease (230).
• Combats neurodegenerative disease via improvement of cognitive function, daily living activity, and global clinical assessment in participants with Alzheimer’s disease (230).

Proper Use of This Supplement

Suggested Use: As a dietary supplement take two (2) veggie capsules once a day. For best results take 20-30 minutes before a meal with an 8 oz glass of water, or as directed by your health care professional.